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3-Dioxygenase Inhibitors in Salvage Therapy for Non-Muscle Invasive Bladder Cancer
Smiles: N#CC1C(=O)NC(=CC=1C1C=CC=CC=1)C1=CC(Br)=CC=C1O
Vuylsteke P
Fedratinib
5 μM and 0
WDR5-C47 - WDR5-MLL (SET1) Antagonist. CAS# 1422389-91-0 0020 3-Dioxygenase Inhibitors in Salvage TherapyWDR5 C47, CAS No. 1422389 91 0, is a highly potent and selective antagonist of WDR5 MLL interaction with an IC50 ~0. 3 M. WDR5 C47 was designed based on the structure of the WDR5 MLL complex. The WD40 repeat protein WDR5 plays a critical role in maintaining the integrity of the MLL complex and fully activating its methyltransferase function. The MLL complex, the trithorax like family of SET1 methyltransferase, catalyzes trimethylation of lysine 4 on
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