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3)15(19)10-14-20(16
InChi: InChI=1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H
with an IC50 of <3 nM for DNA-PK
InChiKey: FMBGOORJEKQQLG-JUZZZACGSA-N
Formula: C10H17N3S
CHMFL-ABL-053 21061 3)15(19)10-14-20(16CHMFL ABL 053 (compound 18a) is a BCR ABL inhibitor with ABL1: IC50 of 70 nM. CHMFL ABL 053 is derived from a dihydropyrimidopyrimidine core scaffold based compound 27 (GNF 7). CHMFL ABL 053 inhibited the proliferation of CML cell lines K562 (GI50 = 14 nM), KU812 (GI50 = 25 nM) and MEG 01 (GI50 = 16 nM), through significant suppression of the BCR ABL auto phosphorylation (EC50 = 100 nM) and downstream mediators such as STAT5, Crkl and ERK's
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