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to bind glycogen synthase kinase-3
resulting in constitutive activation
which does not allow the beta-lactamases to bind
InChi: InChI=1S/C25H34N6O3/c1-17(2)22-16-34-25(33)31(22)23-9-10-26-24(28-23)27-18(3)21-7-5-20(6-8-21)15-29-11-13-30(14-12-29)19(4)32/h5-10
AZD5438 is a potent inhibitor of cyclin-dependent kinase (cdk) 1
Naratriptan icorandil to bind glycogen synthase kinase-3Naratriptan is a selective 5 HT1 receptor subtype agonist for the treatment of migraine headache. Naratriptan binds with high affinity to human cloned 5 HT1B 1D receptors. Migraines are likely due to local cranial vasodilatation and or to the release of sensory neuropeptides (including substance P and calcitonin gene related peptide) through nerve endings in the trigeminal system. The therapeutic activity of AMERGE for the treatment of migraine
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