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25(18-19):3186-94
10-oxygenated protoberberine
InChi: InChI=1S/C20H16O5/c1-10(2)3-4-11-7-14-17(9-15(11)22)25-20(23)18-13-6-5-12(21)8-16(13)24-19(14)18/h3
safe and effective HIV-1 attachment inhibitor
Chemical Name: 4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1
SB 242084 Catalog No.:M21140-C 25(18-19):3186-94SB 242084 is a 5 HT2C receptor antagonist(pKi=9. 0) that displays 158 and 100 fold selectivity over 5 HT2A and 5 HT2B receptors respectively. IC50 value: 9. 0(pKi) Target: 5 HT2C antagonistin vitro: SB 242084 had over 100 fold selectivity over a range of other 5 HT, dopamine and adrenergic receptors. In studies of 5 HT stimulated phosphatidylinositol hydrolysis using SH SY5Y cells stably expressing the cloned human 5 HT2C receptor, SB 242084 acted as
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