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CFTR(Inh) 172
InChiKey: ONIQOQHATWINJY-UHFFFAOYSA-N
40)/t27-/m0/s1
BAF312 was orally dosed once daily at 0
1154097-71-8
SJF 8240 Catalog No.:M7582-2 CFTR(Inh) 172c MET PROTACDegrader. Comprises MET inhibitor foretinib (GSK 1363089; Cat. No. 6056) joined by a linker to a von Hippel Lindau (VHL) recruiting ligand. Degrades c MET within 6 hours in vitro. Inhibits agonist driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66. 7 nM). Also degrades exon 14 deleted c MET in Hs746T cells. Product information CAS Number: 2230821 68 6 Molecular Weight: 1106. 24 Formula: C58H65F2N7O11S Synonym: SJF 8240
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