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Smiles: CC1=CC=CC(NC(=O)C=C)=C1NC1=NC2=CC=C(C=C2C=N1)C1C(Cl)=C(C=C(OC)C=1Cl)OC
also known as NSC 13316
28(11):4901-13
InChiKey: JAMULYFATHSZJM-UHFFFAOYSA-N
In contrast to other commonly used TGFβ receptor (ALK) inhibitors
PF-06282999 - CAS# 1435467-37-0 size:10mg solid Smiles: CC1=CC=CC(NC(=O)C=C)=C1NC1=NC2=CC=C(C=C2C=N1)C1C(Cl)=C(C=C(OC)C=1Cl)OCPF 06282999, CAS No. 1435467 37 0, is a potent and selective myeloperoxidase Inhibitor which is potential useful for the Treatment of Cardiovascular Diseases. PF 06282999 displayed excellent oral pharmacokinetics in preclinical species and robust irreversible inhibition of plasma MPO activity both in human blood stimulated exogenously and in plasma collected after oral (po) administration to lipopolysaccharide (LPS) treated cynomolgus monkeys. PF
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