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The compounds modulate PD-1/PD-L1 protein/protein interaction and are useful in the treatment of various diseases including infectious diseases and cancer
Irisflorentin (10-40 μM) concentration-dependently suppresses LPS-induced p38 and ERK1/2 phosphorylation in a concentration-dependent manner
with an pEC50 of 7
SB 243213 is an orally active
Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome
LP-184 490olCDE-IN-2 The compounds modulate PD-1/PD-L1 protein/proteinLP 184 (compound 6), an acylfulvene analog, inhibits tumor growth. LP 184 has potent anti cancer activity in the ovarian, colon, prostate and pancreatic cell lines. (patent WO2007019308A2). Product information CAS Number: 924835 67 6 Molecular Weight: 304. 34 Formula: C16H20N2O4 Chemical Name: 1 hydroxy 1 {[(6'R) 6' hydroxy 2',4',6' trimethyl 7' oxo 6',7' dihydrospiro[cyclopropane 1,5' inden] 3' yl]methyl}urea Smiles: