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Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms
through the induction of early cell cycle arrest and apoptosis
SB-431542 was used at 10 µM concentration in cell culture
NSC697923 shows cytotoxic effect
14H2/t21-/m1/s1
SB431542 - TGF-beta Inhibitor. CAS# 301836-41-9 60306 Hedgehog signaling antagonist GDC-0449 (Vismodegib)SB 431542, CAS No. 301836 41 9, is a potent and selective inhibitor of TGF type I receptors ALK5 (IC50 ~94 nM), ALK4 (IC50 ~140 nM) and ALK7. It has no activities on the other ALK family members such as ALK2, ALK3 and ALK6, nor on components of the ERK, JNK, and p38 MAP kinase pathways. It specifically blocks Smad2 signaling, modulating gene expression related to EMT. In several publications SB 431542 has been used to enhance iPSC reprogramming,
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