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50(8):1876-85
InChi: InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15
The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins
RVX-208 increases the production of ApoA-I in hepatocytes in vitro
Gonzalez R
MLN8237 (Alisertib) - Aurora A inhibitor. CAS# 1028486-01-2 60125 50(8):1876-85MLN8237 (Alisertib), CAS No. 1028486 01 2, is a highly potent and selective Aurora A inhibitor with an IC50 of 1. 2 nM, >200 fold selective towards structurally related Aurora B (IC50 of 396. 5 nM). It does not have any significant activity against 205 other kinases. MLN8237 treatment inhibits the phosphorylation of Aurora A in MM1. S and OPM1 cells, without affecting the Aurora B mediated histone H3 phosphorylation. MLN8237 significantly inhibits
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