RS-127445 - CAS# 199864-87-4 60433 59865-13-3

Name: RS-127445 - CAS# 199864-87-4 60433 59865-13-3
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Description

59865-13-3

RS-127445 - CAS# 199864-87-4 60433 59865-13-3RS 127445, CAS No. 199864 87 4 , is a selective; high affinity; orally bioavailable serotonin 5 HT2B receptor antagonist. RS 127445 was found to have nanomolar affinity for the 5 HT2B receptor (pKi = 9. 5+ 0. 1) and 1, 000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites. RS 127445 potently antagonized 5 HT evoked formation of inositol phosphates (pK(B) = 9. 5+ 0. 1) and 5 HT evoked increases in

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