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Endothelin-dependent effects limit flow-induced dilation of conductance coronary vessels after blockade of nitric oxide formation in conscious dogs
Polyamines are involved in nucleosome oligomerization and DNA conformation
PubMed PMID: 25515519
(2005) Cardiovasc Drug Rev
3(11):e428]
Lometrexol hydrate - CAS# 1435784-14-7 Size:2mg solid Endothelin-dependent effects limit flow-induced dilationLometrexol hydrate (DDATHF hydrate), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity. Lometrexol hydrate also is a potent human Serine
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