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Solubility: DMSO 40 mg/mL (83
InChi: InChI=1S/C27H31FN4O2/c1-19-9-6-7-14-24(19)26(27(34)30-22-11-4-3-5-12-22)32(23-13-8-10-21(28)17-23)25(33)18-31-16-15-29-20(31)2/h6-10
Astilbin undergoes extensive biotransformation specifically due to enzyme catechol-O-methyl transferase
SKL2001 is an agonist of the Wnt/β-catenin pathway
Molecular Weight: 289
Danoprevir 2-yl)ethane-1 2-diamine hydrochloride Solubility: DMSO 40 mg/mL (83Danoprevir, also known as ITMN 191 and RG 7227, is under development by InterMune Inc and Roche Holding AG, is a promising, potent NS3 4A protease inhibitor for the oral treatment of HCV infection. Preclinical data demonstrated that danoprevir binds with high affinity and dissociates slowly from the HCV NS3 protease, allowing high liver drug exposure with only modest plasma drug exposure. A phase Ib, 'IFN free' clinical trial demonstrated that
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