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Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
In combination with CHIR99021
in liver microsomes of rats
Formula: C18H17ClN2O3S
CAS Number: 1450824-22-2
MGL-3196 - CAS# 920509-32-6 PTO-253 Inhibition of SIRT1 catalytic activityMGL 3196, CAS No. 920509 32 6, also known as Resmetirom, is a potent and highly selective thyroid hormone receptor agonist in clinical trials for the treatment of dyslipidemia. The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor (THR ) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor (THR ). Product information CAS Number:
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