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inhibition of ROCK pathway is believed to contribute to some of the cardiovascular benefits of statin therapy that are independent of lipid lowering (ie
GSK 3117391A
Peptide and small molecule inhibitors of HECT-type ubiquitin ligases
Formula: C22H16F4N6O2
PubMed PMID: 25854303
OSU-03012 60331 inhibition of ROCK pathway isOSU03012; also known as AR12, is an orally available, targeted anti cancer agent that has been shown in pre clinical studies to inhibit PDK 1, a protein in the PI3K Akt pathway that is involved in the growth and proliferation of cells, including cancer cells. AR 12 may also cause cell death through the induction of stress in the endoplasmic reticulum. We are currently conducting a multi centered Phase I clinical study of AR 12 in adult patients with
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