UK-5099 - CAS# 56396-35-1 66052 Smiles: CC(C)C1=NC(=C2C(N)=NC=CN21)C1=CC=C(NC(=O)NC2=CC(=CC=C2)C(F)(F)F)C2=CC=CC=C21

Smiles: CC(C)C1=NC(=C2C(N)=NC=CN21)C1=CC=C(NC(=O)NC2=CC(=CC=C2)C(F)(F)F)C2=CC=CC=C21

NVP-TAE684 suppresses lymphomagenesis in two independent models of ALK-positive ALCL and induces regression of established Karpas-299 lymphomas

Formula: C14H19BCl2N2O4

5 MTD dose of Bortezomib (0

10% Tween 80

UK-5099 - CAS# 56396-35-1 66052 Smiles: CC(C)C1=NC(=C2C(N)=NC=CN21)C1=CC=C(NC(=O)NC2=CC(=CC=C2)C(F)(F)F)C2=CC=CC=C21UK 5099, CAS No. 56396 35 1, is a specific and potent mitochondrial pyruvate carrier blocker (MCK blocker). The UK5099 treated cells showed significantly higher proportion of side population (SP) fraction and expressed higher levels of stemness markers Oct3 4 and Nanog. Chemosensitivity examinations revealed that the UK5099 treated cells became more resistant to chemotherapy compared to the non treated cells. MPC blocker (UK5099) application may be an