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and CDK1 with IC50 of 35 nM
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Woodhead SJ
MDK7526 binds androgen receptor such that androgen receptor is placed in proximity to the ubiquitin ligase to effect degrdn
Smiles: CN(C)C(=S)NN=C(C1=CC=CC=N1)C1=CC=CC=N1
TBK1/IKKε-IN-1(compound 1) Catalog No.:M7456-2 and CDK1 with IC50 ofTBK1 IKK IN 1 (compound 1) is a dual inhibitor of TANK binding kinase 1 (TBK1) and IB kinase (IKK IKK i) with IC50 of 1. 0 nM and 5. 6 nM for TBK1 and IKK, respectively. TBK1 IKK inhibition enhances response to PD 1 blockade, which effectively predicts tumor response in vivo. Product information CAS Number: 1893397 65 3 Molecular Weight: 513. 59 Formula: C28H31N7O3 Chemical Name: 5 (4 ((4 (4 (oxetan 3 yl)piperazin 1 yl)phenyl)amino) 1,3,5 triazin 2
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