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ARQ 621 Catalog No.:M19604-C 4-dimethyl-1H-1

SKU: 44882978735

4.5
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Description

4-dimethyl-1H-1

targeting cancer mutations via FGFR inhibition FGFR1 (IC50=6 nM)

O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays

Ilginatinib hydrochloride shows potent inhibitory activity against cell lines JAK2V617F or MPLW515L mutations or the TEL-JAK2 fusion gene (expressing a constitutively activated JAK2) with IC50 of 11-120 nM

GNE-272 is also a selective in vivo probe for CBP/EP300

ARQ 621 Catalog No.:M19604-C 4-dimethyl-1H-1ARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule based ATPase motor protein involved in cell division. Anti tumor activity. ARQ 621 is a kinesin inhibitor. Product information CAS Number: 1095253 39 6 Molecular Weight: 552. 43 Formula: C28H24Cl2FN5O2 Chemical Name: N (3 aminopropyl) 3 chloro N [(1R) 1 [7 chloro 4 oxo 3 (phenylamino) 3,4 dihydroquinazolin 2 yl]but 3 yn 1 yl] 2 fluorobenzamide Smiles:

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