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27(40):5315-25
Mechanistic studies showed that Spautin-1 inhibited two ubiquitin specific peptidases
It inhibits histone demethylase JMJD3
129:453-461
Chambers SK
Wnt-C59 - Wnt Antagonist. CAS# 1243243-89-1 size:10mg solid 27(40):5315-25Wnt C59, CAS No. 1243243 89 1, is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. It prevents palmitylation of Wnt proteins by Porcupine (a membrane bound O acyltransferase), thereby blocking Wnt protein secretion and activity. Wnt C59 displayed good bioavailability as once daily oral administration and blocked progression of mammary tumors in MMTV WNT1 transgenic mice model while
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