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Inhibits MEK-1 and MEK-2 (IC50 values of 0
110(36):14622-7
It is moderately toxic to mammals
InChiKey: VPTPBEUWKCLZGU-OOSWLFMASA-N
apparent t1/2 (2
TRAM 39 13081 Inhibits MEK-1 and MEK-2 (IC50TRAM 39, 2 (2 chlorophenyl) 2, 2 diphenyl acetonitrile, is a potent, synthetic, selective inhibitor of intermediate conductance Ca2+ activated K+channels. TRAM 39 selectively block K Ca3 but do not inhibit other Ca2+ activated K+channels.[1,3] Intermediate conductance Ca2 activated K channels are the product of the IKCa1 genes and are important in regulating the membrane potential of colonic epithelial cells, and lymphocytes. The IKCa1 gene is also
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