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Torin-1 did not affect the survival of normal colon stem cells in vivo
the ADC payload will only be released in the cell
is a small molecule that simultaneously degrades β-catenin and Ras by inhibition of the Wnt/β-catenin pathway
and FGFR4 with IC50=60 nM
Dumitras S
PF-4136309 - CAS# 1341224-83-6 273 Torin-1 did not affect thePF 4136309, CAS No. 1341224 83 6, also known as INCB8761, is an orally available human chemokine receptor 2 (CCR2) antagonist with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist PF 04136309 specifically binds to CCR2 and prevents binding of the endothelium derived chemokine ligand CLL2 (monocyte chemoattractant protein 1 or MCP1) to its receptor CCR2, which may result in inhibition of CCR2
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