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PubMed Central PMCID: PMC4292866
FPS-ZM1 inhibits RAGE-mediated influx of circulating Aβ40 and Aβ42 into the brain
MLN8237 is currently in Phase II study for treatment of patients with ovarian
Klapproth JM
Smiles: [O-][N+](=O)C1=CC(Cl)=CC=C1S(=O)(=O)C1C=CC=CC=1
Exatecan Mesylate - CAS# 169869-90-3 0271 PubMed Central PMCID: PMC4292866Exatecan Mesylate, CAS No. 169869 90 3, also known as DX 8951, is semisynthetic, water soluble camptothecin derivative with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater