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Toxicol Mech Methods
Epub 2015 Feb 5
37 and 97% TGI
InChiKey: ODIUJYZERXVGEI-UHFFFAOYSA-N
170:226-33
CHIR-124 Size:10mg solid Toxicol Mech MethodsCHIR 124 is a quinolone based small molecule Chk1 inhibitor, that is structurally unrelated to other known inhibitors of Chk1. It potently and selectively inhibits Chk1 in vitro (IC(50) = 0. 0003 micromol L). CHIR 124 interacts synergistically with topoisomerase poisons (e. g., camptothecin or SN 38) in causing growth inhibition in several p53 mutant solid tumor cell lines as determined by isobologram or response surface analysis. CHIR 124 is a novel
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