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6-tert-butyl-3a-carboxyhexahydro-alpha5a
Proglumide sodium selective blocks CCK’s effects in the central nervous system (CNS)
4% at 40 µg/ml and 21
1126/science
LCB 2853 shows an ED50 lower than 1 mg/kg i
BDA-366 Size:Contact [email protected] for quotation 6-tert-butyl-3a-carboxyhexahydro-alpha5aBDA 366 is a selective antagonist of BCL2 BH4 domain with Ki value of 3. 3 nM . BCL2 is an important anti apoptotic protein. BCL2 homology 4 (BH4) domain is required for its antiapoptotic function, thus acts as a promising anticancer target . BDA 366 is a selective BCL2 inhibitor. BDA 366 induced conformational change of BCL2 that exposed the BH3 domain, resulting in abrogation of its prosurvival function and conversion of BCL2 to a prodeath protein.
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