GNE-616 emsirolimus CAS Number: 552325-73-2

CAS Number: 552325-73-2

It also inhibits asparaginyl-hydroxylase factor inhibiting HIF (FIH) and is useful for controlling excess collagen deposition in pathological fibrosis

CAS Number: 12071-83-9

InChiKey: UBPYILGKFZZVDX-UHFFFAOYSA-N

Pharmacokinetic studies reveal that MGAT2-IN-2 displays a high plasma concentration (AUC0-8h=842 ng•h/mL) and favorable oral bioavailability (F=52%)

GNE-616 emsirolimus CAS Number: 552325-73-2GNE 616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1. 7 inhibitor (Ki of 0. 79 nM and Kd of 0. 38 nM for hNav1. 7) for the treatment of chronic pain. GNE 616 shows >1000 nM Kd and >2500 fold selectivity over hNav1. 1, hNav1. 3, hNav1. 4, and hNav1. 5. Selectivity over hNav1. 2 and hNav1. 6 is more modest at 31 and 73 fold, respectively. Product information CAS Number: 2349371 81 7 Molecular Weight: 537. 53