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3-benzodioxol-5-yl)methylidene]-2-oxopyrrolidine-1-carbaldehyde
Evaluation of Acute Toxicity Levels and Ethological Responses Under Tetrachlorocatechol Exposure in Common Carp
inhibition of writhing is 65
InChi: InChI=1S/C13H8Cl2N2O4
Oral administration of GSK269962A produced a profound dose-dependent reduction of systemic blood pressure in spontaneously hypertensive rats
S2116 811CT020312 3-benzodioxol-5-yl)methylidene]-2-oxopyrrolidine-1-carbaldehydeS2116, a N alkylated tranylcypromine (TCP) derivative, is a potent lysine specific demethylase 1 (LSD1) inhibitor. S2116 increases H3K9 methylation and reciprocal H3K27 deacetylation at super enhancer regions. S2116 induces apoptosis in TCP resistant T cell acute lymphoblastic leukemia (T ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2116 significantly retardes the growth of T ALL cells in xenotransplanted mice. Product
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