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Smiles: O=C(NC1=CN=CC=C1)N1CCC(CC2C=C(C=CC=2)OC2=CC=C(C=N2)C(F)(F)F)CC1
2-dithiol-3-one
as well as the endoplasmic reticulum stress response
These results indicate CI-1040 exerts its effects on cells by suppressing the activation of MKK1
with TGI of 88% and 97%
Obatoclax (GX15-070) Size:2mg solid Smiles: O=C(NC1=CN=CC=C1)N1CCC(CC2C=C(C=CC=2)OC2=CC=C(C=N2)C(F)(F)F)CC1Obatoclax, also known as GX 015 070, a synthetic small molecule inhibitor of the bcl 2 family of proteins with potential pro apoptotic and antineoplastic activities. Obatoclax binds to members of the Bcl 2 protein family, preventing the binding of these anti apoptotic proteins to the pro apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl 2 overexpressing cells. The Bcl 2 family of proteins (bcl 2, bcl xl,