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3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner
with IC50s of 8 and 6 µM at 48 and 72 h
InChi: InChI=1S/C5H13NO2/c1-7-4-5-8-3-2-6/h2-6H2
TAK-491 monopotassium
CAS Number: 516480-79-8
BI-9627 Catalog No.:M21408-C 3 nM-30 μM) and CholesterolBI 9627 is potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI 9627 displays >30 fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI 9627 shows low DDI (drug drug interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart
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