RGFP966(EE) - CAS# 1396841-57-8 805 dihydrochloride 63(2):601-612

63(2):601-612

NSC59984 induces mutant p53 protein degradation through MDM2-mediated ubiquitination in cancer cells

InChi: InChI=1S/C19H22N8O6S2

degrades clinically relevant androgen receptor point mutants and unlike enzalutamide

PSI-7977 13CD3

RGFP966(EE) - CAS# 1396841-57-8 805 dihydrochloride 63(2):601-612RGFP966 is a selective HDAC3 inhibitor . S ystemic treatment with RGFP966 facilitates extinction in mice in a manner resistant to reinstatement. A single treatment of RGFP966 enhances extinction of a previously established cocaine conditioned place preference, while simultaneously enhancing long term object location memory within subjects. During extinction consolidation, HDAC3 inhibition promotes a distinct pattern of histone acetylation linked to