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thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors
The IC50 values against Daudi and HL-60 cells are 15
Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules
An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers
InChiKey: VWBDGXJRQZDLRV-CSKARUKUSA-N
AMG 232 Catalog No.:M8600-2 thereby inhibiting receptor phosphorylation andAMG232 is an extremely potent MDM2 inhibitor (SPR KD = 0. 045 nM, SJSA 1 EdU IC50 = 9. 1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA 1 osteosarcoma xenograft model (ED50 = 9. 1 mg kg). AMG232 is currently under clinical development. Product information CAS Number: 1352066 68 2 Molecular Weight: 568. 55 Formula: C28H35Cl2NO5S Synonym: AMG232 AMG 232 Chemical Name: 2 [(3R,5R,6S) 5 (3 chlorophenyl) 6 (4
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