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6-trimethyl-N-((3'-(methylsulfonyl)-[1
Formula: C6H11ClN4
Protein lysine methyltransferase G9a plays key roles in the transcriptional repression of a variety of genes via dimethylation of lysine 9 on histone H3 (H3K9me2) of chromatin as well as dimethylation of nonhistone proteins including tumor suppressor p53
TPEN (TPEDA) is a specific cell-permeable heavy metal chelator that induces apoptosis in NB4 cells via negatively regulating intracellular NO and Zn2+ signaling
Kordi Jaz E
IM-250 isantherin A 6-trimethyl-N-((3'-(methylsulfonyl)-[1IM 250 not only reduces the duration of disease symptoms or time to healing but also prevents recurrent disease in guinea pigs. Treatment of recurrent infections reduces the frequency of recurrences and viral shedding, and, unlike nucleosidic drugs, IM 250 remains effective for a time after cessation of treatment. Hence, IM 250 has advantages over standard of care therapies and represents a promising therapeutic for chronic HSV infection, including
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