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It also inhibits the cytochrome P450 (CYP) isoforms CYP2C9 and CYP2C19 (IC50s = 13 and 8 μM
but shows no effects on SIRT3 protein expression
NVP-231 (0-500 nM
InChiKey: OTGPYEHFRKGRIZ-UHFFFAOYSA-N
Formula: C17H19F2N7O3S2
PF-03814735 - CAS# 942487-16-3 Catalog No.:M10382-2 It also inhibits the cytochromePF 03814735 is an orally bioavailable, ATP competitive, reversible small molecule Aurora kinase inhibitor with potential antineoplastic activity. Aurora kinase inhibitor PF 03814735 binds to and inhibits Aurora kinases A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine threonine kinases that play essential roles in mitotic checkpoint control during
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