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JKE-1674 exhibits activity indistinguishable from that of ML210 in cellular target engagement assays including yielding the same +434Da GPX4 adduct in cells
CAS Number: 484-76-4
3-tetrahydrospiro[indene-2
1169211-37-3 (free base)
RIP2 kinase is composed of an N-terminal kinase domain and a C-terminal caspase-recruitment domain (CARD) linked via an intermediate (IM) region
GSK-626616 Catalog No.:M16884-C JKE-1674 exhibits activity indistinguishable fromGSK 626616 is a potent, orally bioavailable inhibitor of DYRK3 (IC50=0. 7 nM). GSK 626616 inhibits other members of the DYRK family (e. g., DYRK1A and DYRK2) with similar potency, which is a potential therapy for the treatment of anemia. Product information CAS Number: 1025821 33 3 Molecular Weight: 401. 27 Formula: C18H10Cl2N4OS Chemical Name: (Z) 2 ((2, 6 dichlorophenyl)amino) 5 (quinoxalin 6 ylmethylene)thiazol 4(5H) one Smiles:
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