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Formula: C29H31N5O4
KDM5-C49 was used at 1-10 µM in vitro
11 cells and also low nanomolar IC50 values in a panel of leukemia cell lines
Jacobson IM
It first became available in Europe in 1984
RG7112 - CAS# 939981-39-2 dine D6 Hydrochloride Formula: C29H31N5O4RO5045337, also known as RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2 p53 interaction, the proteosome mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53
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